DR.HYTHAM KADOUR

هذا المنتدى هو للتعارف و تبادل العلوم و الثقافات المختلفة
 
الرئيسيةبحـثالتسجيلالأعضاءدخول

شاطر | 
 

 Venlafaxine painful diabetic neuropathy

اذهب الى الأسفل 
كاتب الموضوعرسالة
د هيثم قدور
Admin
avatar

ذكر
عدد الرسائل : 85
العمر : 49
الموقع : http://naji1969.montadarabi.com
العمل/الترفيه : dentist
تاريخ التسجيل : 23/02/2008

مُساهمةموضوع: Venlafaxine painful diabetic neuropathy   الإثنين فبراير 25, 2008 4:48 am

Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study.

Rowbotham MC, Goli V, Kunz NR, Lei D
UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA, USA. mcrwind@itsa.ucsf.edu Pain (2004)

To evaluate the efficacy and safety of 6 weeks of venlafaxine extended-release (ER) (75 mg and 150-225 mg) treatment in patients with painful diabetic neuropathy. This multicenter, double-blind, randomized, placebo-controlled study included 244 adult outpatients with metabolically stable type 1 or 2 diabetes with painful diabetic neuropathy. Primary efficacy measures were scores on the daily 100 mm Visual Analog Pain Intensity (VAS-PI) and Pain Relief (VAS-PR) scales. Secondary efficacy measures included the Clinical Global Impressions-Severity of Illness and the Clinical Global Impressions-Improvement, Patient Global Rating of Pain Relief, and percentage of patients achieving 50% reduction in pain intensity. Baseline pain intensity was 68.7 mm (moderately severe). At week 6, the percentage reduction from baseline in VAS-PI was 27% (placebo), 32% (75 mg), and 50% (150-225 mg; P < 0.001 vs placebo). Mean VAS-PR scores in the 150-225 mg group were significantly greater than placebo at week 6 (44 vs 60 mm; P < 0.001). The number needed to treat (NNT) for 50% pain intensity reduction with venlafaxine ER 150-225 mg was 4.5 at week 6. Nausea and somnolence were the most common treatment-emergent adverse events. Seven patients on venlafaxine had clinically important ECG changes during treatment. Venlafaxine ER appears effective and safe in relieving pain associated with diabetic neuropathy. NNT values for higher dose venlafaxine ER are comparable to those of tricyclic antidepressants and the anticonvulsant gabapentin.



الرجوع الى أعلى الصفحة اذهب الى الأسفل
معاينة صفحة البيانات الشخصي للعضو http://naji1969.montadarabi.com
 
Venlafaxine painful diabetic neuropathy
الرجوع الى أعلى الصفحة 
صفحة 1 من اصل 1

صلاحيات هذا المنتدى:لاتستطيع الرد على المواضيع في هذا المنتدى
DR.HYTHAM KADOUR :: الطب و الصحة :: منشورات و ردود خاصة-
انتقل الى: