DR.HYTHAM KADOUR

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 Vitamin D Ergocalciferol

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تاريخ التسجيل : 23/02/2008

مُساهمةموضوع: Vitamin D Ergocalciferol   الإثنين فبراير 25, 2008 5:29 am

FDA Information > Vitamin D Ergocalciferol
Vitamin D Ergocalciferol
Generic Name: ergocalciferol
Dosage Form: Softgels soft gelatin capsules
Carcinogenesis, Mutagenesis, Impairment of Fertility
No long-term animal studies have been performed to evaluate the drug's potential in these areas.
Pregnancy :
Pregnancy Category C.
Animal reproduction studies have shown fetal abnormalities in several species associated with hypervitaminosis D. These are similar to the supravalvular aortic stenosis syndrome described in infants by Black in England (1963). This syndrome was characterized by supravalvular aortic stenosis, elfin facies, and mental retardation. For the protection of the fetus, therefore, the use of vitamin D in excess of the recommended dietary allowance during normal pregnancy should be avoided unless, in the judgment of the physician, potential benefits in a specific, unique case outweigh the significant hazards involved. The safety in excess of 400 USP units of vitamin D daily during pregnancy has not been established.
Nursing Mothers :
Caution should be exercised when ergocalciferol is administered to a nursing woman. In a mother given large doses of vitamin D, 25-hydroxycholecalciferol appeared in the milk and caused hypercalcemia in her child. Monitoring of the infants serum calcium concentration is required in that case (Goldberg, 1972).
Selected references
1. Akcam M, Yildiz M, Yilmaz A, et al. Bone mineral density in response to two different regimes in rickets. Indian Pediatr. 2006 May;43(5):423-7.
2. Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine 2003;28(2):177-179.
3. Alhava EM, Aukee S, Karjalainen P, et al. The influence of calcium and calcium + vitamin D2 treatment on bone mineral after partial gastrectomy. Scand J Gastroenterol 1975;10(7):689-693.
4. Arnas LAG, Heaney RP, Hollis BW. Vitamin D2 is much less effective than vitamin D3 in humans (abstract OR22-2). The Endocrine Society 86th Annual Meeting 2005;
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Vitamin D Ergocalciferol
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