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 Bromelain Safety Issues

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عدد الرسائل : 85
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تاريخ التسجيل : 23/02/2008

مُساهمةموضوع: Bromelain Safety Issues   الإثنين فبراير 25, 2008 5:30 am

Safety Issues
Bromelain appears to be essentially nontoxic, and it seldom causes side effects other than occasional mild gastrointestinal distress or allergic reactions. 41
However, because bromelain "thins" the blood to some extent, it shouldn't be combined with drugs such as Coumadin ( warfarin ) without a doctor's supervision.
According to one small animal study, bromelain might interact with sedative medications, increasing their effect. 42 As noted above, it might also increase blood levels of various antibiotics , which could present risks in some cases. In addition, one trial suggests that doses of bromelain eight times higher than standard recommendations might increase heart rate (but not blood pressure). 47
Safety in young children, pregnant or nursing women, or those with liver or kidney disease has not been established
1. Kane S, Goldberg MJ. Use of bromelain for mild ulcerative colitis [letter]. Ann Intern Med. 2000;132:680.
2. Taussig SJ, Yokoyama MM, Chinen A, et al. Bromelain, a proteolytic enzyme and its clinical application. A review. Hiroshima J Med Sci . 1975;24:185–193.
3. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple ( Ananas comosus ) and its clinical application. An update. J Ethnopharmacol . 1988;22:191–203.
4. Moshal MG. Nutrizym as a pancreatic enzyme replacement. S Afr Med J. 1974;48:1489–1490.
5. Knill-Jones RP, Pearce H, Batten J, et al. Comparative trial of Nutrizym in chronic pancreatic insufficiency. Br Med J. 1970;4:21–24.
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Bromelain Safety Issues
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