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 Vioxx and Celebrex 'ncreas_ Health Risk?

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عدد الرسائل : 85
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تاريخ التسجيل : 23/02/2008

مُساهمةموضوع: Vioxx and Celebrex 'ncreas_ Health Risk?   الإثنين فبراير 25, 2008 5:38 am

Vioxx and Celebrex 'ncreas_ Health Risk?

Tuesday, March 13, 2001; Page HE06

COULD VIOXX AND CELEBREY- INCREASE HEART RISK? Two studies conducted by the makers of these very expensive, very popular arthritis drug_ raise this worrisome question.

Merck (maker of Celebrex) and Pharmacia (Vioxx) submitted the studies to the FDA to help convince the agency to remove some label warnings. Vioxx, Pharmacia's study showed, was a little safer on the stomach (the purported advantage of both drugs) than a high-dose, prescription version of Aleve, but Vioxx worked no better to relieve arthritis symptoms --. and takers had significantly more heart attacks, hypertension and other heart-related side effects. In M.erck's study, Celebrex was no safer on the stomach than either a prescription or OTC anti-inflammatory, and Celebrex takers seemed mbre likely to have chest pain and heart attacks.

FDA committee members concluded the safety warnings should remain, the risk of heart problems should be addt'.d to labels -- and that the cardiovascular side efrects need a c1oser look. The companies link the effects to the fact that their drugs, unlike those to which they were compared, lack blood-thinning effects -- not entirely a bad thing.

UNDER THE BAR Many high protein/low carbohydrate bars contain less protein and more carbs than they claim, says the National Consumers League. The group tested Met-Rx Protein Plus, Atkins Diet Advantage, Premier Protein and other bars dieters and athletes use for energy and quick meals. The results might get some bars cut from the team. Among tricks used to understate carbs: Labels omit glycerin-- a sweetener -- from the "total carbohydrates" declaration. ,'\l!d labels tout "high protein" without stating how much of the daily protein requirement the bars provide .-- a violation of Jabelirig regs¬

NCL accused the makers of exploiting the high-protein/low..carb craze and urged FDA actio11.

Jhe FDA i;mnQun£ed that 1151lliillt?JakinQ.. Vioxx have a 50 Dercen!; great_LQJan_C;_Qf head;_1taQ§ and suddlf_ns_ardiac death. The study, presented at an epidemiologists conference, also found patients takinq the hi.9.D_$t recomr11_nded dailv dosaQe of Vioxx had thre_.JJmes the risk of heart attack aild sudden cO1rdjacJ!eaU)L as those not taki_tanqp.nt'paink!lIers.

The popular and heavily advertised arthritis drugs Vioxx and Celebrex have been linked by researchers to an increase in the risk of blood clots, heart attack_; and strokes.The study from the Cleveland Clinic appeared in the Journal of the Arne,ican Medical /\ssociation and was based on an analysis of previous clinical trials. Celebrex and Vioxx are projected to produce U.s. sales greater than $6 billion this year.

In a study of more than 8,000 patients that compared the COX-2 inhibitor rofecoxib (Vioxx) with the traditional NSAID naproxen,j:_!J_Ji::,k of cardiovascular .problem.J!.rJrlciudinqJl_art attack, chest p_in related to heart disease, s_rgl-{e, :sudden death and blQQ.d clo.!fu was more t!:l<liLtWQ tim._s hi9..!:l_I in the rofecox!!Ulroup than in.!t_".! na_rox_rLm:_QYIh

Vioxx and Celebrex are classified as and known as COX-2 inhibitors, or coxibs. COX-2 inhibitors, like older' drugs such as ibuprofen and naproxen, are nonst,_roidal anti-inflammatory drugs, or NSAIDs. Older NSAIDs reduce inflammation by blccking an enzyme called COX-2, but tlley also block another enzyme called COX-i. This enzyme helps protect the lining of the stomach, so blocking COX-2 can cause stomach irritation. COX-2 intlibitors only biock COX-2, leaving the stomach-protecting COX-i alone.

The annual rates of heart aU",ci: in both the Celebrex celecoxib) and Vioxx __c;_ig) studies were increased compared to ,_ review of studies contah'u a 0 al of more t an , 0 patients, In those studies, 10.52% of patients taking an inactive placebo pill h",d a heart attack each year. The annual rate (.If h"","rt attad< w._s 0.74% fQf patients taidng rofecoxib and a.aOok for those _aki!ig celt'!!coxib.
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